does ashwagandha interact with medications does ashwagandha interact with medications

View abstract. J Ayurveda Integr Med. Is it safe to take ashwagandha every day? 1965;9(3):127-136. Go to the ER right away. Critical review of theWithania somnifera(L.) Dunal: ethnobotany, pharmacological efficacy, and commercialization significance in Africa. metoprolol, nebivolol, propranolol), Diuretics (e.g. It may cause you to become sleepy or drowsy. Although side effects do not always occur, you may experience drowsiness, stomach pain, or loose stools when taking ashwagandha. Ashwagandha dosing may vary by brand or reason for use. View abstract. Withania somnifera, known as ashwagandha, has a role in ayurvedic medicine for a wide range of health conditions. 2014;20(12):901-908. doi:10.1089/acm.2014.0177, Remenapp A, Coyle K, Orange T, et al. 2008;6:14. J Altern Complement Med. 2020;40(4):825-829. losartan, valsartan, telmisartan), Beta-Blockers (e.g. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Many of the studies on ashwagandha have been performed in laboratory settings or on animal models, but some human trials do exist. Some symptoms of high thyroid hormone levels include fatigue, increased appetite, sweating, restlessness, diarrhea, hair loss, insomnia, itching and high blood pressure. It's best to talk to your doctor before you start taking antidepressants and vitamins, especially mixed supplements. 2019;11(9):e5797. Withania somnifera, also commonly as ashwagandha or winter cherry, is a shrub native to parts of Asia and Africa. Serotonin syndrome can even result in death. Myxedema Coma. According to the Cleveland Clinic, there are six different types of medications commonly used to treat depression. National Center for Complementary and Integrative Health. There aren't any specific antidiabetic drugs ashwagandha is known to interact with. Effects of ashwagandha (Withania somnifera) on physical performance: systematic review and Bayesian meta-analysis. PLoS One 2009;4:e6628. We comply with the HONcode standard for trustworthy health information. In this randomized, double-blind, placebo-controlled trial, 125 adult participants were randomized to either 300 milligrams per day of ashwagandha sustained release or a placebo for 90 days. Some of these sedative medications include clonazepam (Klonopin), diazepam (Valium), lorazepam (Ativan), and others. Evaluation of the efficacy of withania somnifera (ashwagandha) root extract in patients with obsessive-compulsive disorder: a randomized double-blind placebo-controlled trial. A study compared ashwagandha to a placebo to determine whether the herb would have a positive effect on insomnia. This herbal medicine term means that this substance is thought to help the body respond to mental and physical stress and to restore normal emotional and physical body function. 2005 - 2023 WebMD LLC, an Internet Brands company. Those who took 600 milligrams per day of ashwagandha had better results than those in the 250 milligrams per day group, yet both groups saw improvements in stress. Does Ashwagandha Interact With Any Medications? Ashwagandha contains several active constituents including: The mechanism of how ashwagandha works, for all of its purported benefits, is not well understood. Discard any remaining ashwagandha supplements once they expire or as indicated on the packaging. A 2020 case study examined five adults who had experienced signs of hepatotoxicity, or toxicity to the liver, after using ashwagandha in varying doses. Last updated on Feb 3, 2023. Therefore, it is important to talk to your healthcare provider about any supplements you plan to take and check in about potential interactions with other supplements or medications. Therapeutic Research Faculty 2020. Ghosal S, Lal J, Srivastava R, and et al. It does NOT include all information about conditions, treatments, medications, side effects, or risks that may apply to a specific patient. Malhotra, C. L., Mehta, V. L., Prasad, K., and Das, P. K. Studies on Withania ashwagandha, Kaul. Brittany Lubeck, RD, is a nutrition writer and registered dietitian with a master's degree in clinical nutrition. Medicine (Baltimore). Fuladi S, Emami SA, Mohammadpour AH, Karimani A, Manteghi AA, Sahebkar A. View abstract. Ashwagandha can increase the activity of the immune system. What are some herbs that are contraindicated with Cotellic (cobimetinib)? It is just a general precaution that ashwagandha may decrease blood sugar. Ireland PJ, Hardy T, Burt AD, Donnelly MC. Ultimately, the supplements and foods you can safely ingest depend entirely on the antidepressant. Bjrnsson HK, Bjrnsson ES, Avula B, et al. ashwaganda: Dosing, contraindications, side effects, and pill pictures - epocrates online Drug Lookup: Browse: Drugs Alt Meds Select a medication above to begin. Melissa Nieves, LND, RD, is a registered dietitian and licensed nutritionist who works as a bilingual telehealth dietitian. Taking ashwagandha along with medications that lower blood pressure might cause blood pressure to go too low. Sharada, A. C., Solomon, F. E., Devi, P. U., Udupa, N., and Srinivasan, K. K. Antitumor and radiosensitizing effects of withaferin A on mouse Ehrlich ascites carcinoma in vivo. 2021 Feb 11;6(1):20. doi: 10.3390/jfmk6010020. J Altern Complement Med. According to one study that examined ashwagandha's effect on athletics, ashwagandha may improve both endurance and recovery in healthy adult athletes. These are: In addition to these commonly prescribed antidepressants, there are other central nervous system drugs with antidepressant effects, like antipsychotics, as well as herbs and supplements that have natural antidepressant properties. Hi, I was recommended to take ashwagandha. Also learn why ingredients such as alpha-lipoic acid, soy, resveratrol, quercetin may impair thyroid function. Indian J Physiol Pharmacol. Herbal supplements, like St. John's wort or garcinia cambogia, are much more likely to affect the functionality of your antidepressants compared to vitamins or mineral tablets. Ashwagandha might cause sleepiness and drowsiness. Often, herbs and supplements come with a risk of side effects. 1998;20(1):191-198. Taking ashwagandha along with diabetes medications might cause blood sugar to drop too low. Brain Behav. Altern Med Rev 2000;5:334-46. Consult your doctor before taking ashwagandha if you use digoxin. Studies on immunomodulatory activity of Withania somnifera (Ashwagandha) extracts in experimental immune inflammation. As always, be sure to talk to your doctor about combining any over-the-counter dietary supplement with your prescribed drugs as they have your complete medical profile. Biochem.Biophys.Res Commun. St. John's wort can cause a buildup of serotonin in the body when taken with antidepressants. Are there any side effects of ashwagandha? Researchers from a different study believe that withanone (Win), a bioactive substance found in ashwagandha, is to blame for the liver damage. There is little evidence for its use as an "adaptogen." Ashwagandha contains chemicals that. Neurol India 2009;57:166-71. Sometimes, these supplements are stand-alone products or multivitamins; in other cases, they are mixed in with healthy food products, like spirulina, chlorella or herbal products. You may think that these supplements are safe because they also have antidepressant effects, but it's not that simple. A randomized, double blind, placebo controlled study to evaluate the effects of ashwagandha (Withania somnifera) extract on sleep quality in healthy adults. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Monitor your blood pressure closely. View abstract. Third-party agencies like these confirm that supplements actually contain what they say they do, but they do not approve medical claims. Several supplements and herbs may act similarly to ashwagandha. View abstract. Cureus 2022;14(10):e30433. View abstract. Praveenkumar, V., Kuttan, R., and Kuttan, G. Chemoprotective action of Rasayanas against cyclosphamide toxicity. Immunomodulatory and CNS effects of sitoindosides 9 and 10, two new glycowithanolides from Withania somnifera. Salve J, Pate S, Debnath K, Langade D. Adaptogenic and anxiolytic effects of ashwagandha root extract in healthy adults: A double-blind, randomized, placebo-controlled clinical study. It should not be confused with Physalis alkekengi, which is also referred to as winter cherry. Safety studies have not been performed on these populations, so it's best to avoid using ashwagandha altogether while pregnant or breastfeeding. This can result in serotonin syndrome, which causes side effects like anxiety, sweating, confusion, tremors, lack of coordination and an accelerated heart rate. Gopukumar K, Thanawala S, Somepalli V, Rao TSS, Thamatam VB, Chauhan S. Efficacy and safety of ashwagandha root extract on cognitive functions in healthy, stressed adults: a randomized, double-blind, placebo-controlled study. Indian J Exp Biol. . Ashwagandha has also been used to increase performance among athletes and improve male infertility. Ashwagandha may interact with various medications. J Ethnopharmacol. doi:10.1002/brb3.1760, Adalier N, Parker H. Vitamin E, turmeric and saffron in treatment of Alzheimer's disease. However, you should not stop taking any prescribed medication. 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Bull Natl Res Cent. Most ashwagandha supplements are naturally vegan and gluten-free. Guerrero FA, Medina GM. Notably, ashwagandha doses typically do not exceed 1,000 milligrams per day for up to 12 weeks. Additionally, ashwagandha may increase testosterone levels in the body. It may also interact with medications for these conditions. View abstract. View abstract. Use WebMD's Drug Interaction Checker tool to find and identify potentially harmful and unsafe combinations of prescription medications by entering two or more drugs in question. Created for people with ongoing healthcare needs but benefits everyone. Long term effect of herbal drug Withania somnifera on adjuvant induced arthritis in rats. Medical Content Reviewed By HelloPharmacist Skinmed. Commonly prescribed SSRIs include sertraline (brand name Zoloft), paroxetine (Paxil), fluoxetine (Prozac) and citalopram (Celexa). View abstract. It is not intended to be medical advice or a substitute for the medical advice, diagnosis, or treatment of a health care provider based on the health care provider's examination and assessment of a patients specific and unique circumstances. Ashwagandha is not naturally found in foods, which means the only way to get it is through supplements. Efficacy and safety evaluation of ayurvedic treatment (ashwagandha powder and sidh makardhwaj) in rheumatoid arthritis patients: a pilot perspective study. View abstract. Food Chem.Toxicol. Staff, Cotellic With Turmeric And Black Pepper Interaction. 2009;15(4):423-430. Evid Based Complement Alternat Med. This is because ashwagandha is thought to be an adaptogen, a substance that may help the body resist stress. Hello! Role of an indigenous drug Geriforte on blood levels of biogenic amines and its significance in the treatment of anxiety neurosis. PLoS One. lisinopril, captopril, benazepril, quinapril), ARBs (e.g. 2021;57:102642. doi:10.1016/j.ctim.2020.102642, Bjrnsson HK, Bjrnsson ES, Avula B, et al. View abstract. Do note that ashwagandha itself does not . Vitamin D supplementation improves anxiety but not depression symptoms in patients with vitamin D deficiency. Ashwagandha can interact with diabetes, blood pressure, and immunosuppressant medications. 2020;72:28-36. Ashwagandha's cortisol-lowering effects may be responsible. 2022 Mar 25;14(3):e23494. This is according to a recent review of case studies of liver damage caused by ashwagandha. 8 Warning Signs of Depression You Shouldn't Ignore, Depression in Adults With a Chronic Physical Health Problem: Treatment and Management, How Vegans Can Get All Their Nutrients (Without Taking Supplements), Complementary Therapies in Medicine Journal, 15 Celebrities Who Struggle With Anxiety and Depression, Australian Journal of Herbal Medicine: "B Vitamins Enhance Antidepressant Response in Adults", Open Neurology Journal: "Vitamin B12 Supplementation in Treating Major Depressive Disorder: A Randomized Controlled Trial", Journal of Psychiatry: "Adjunctive Nutraceuticals for Depression: A Systematic Review and Meta-Analyses", Mayo Clinic: "MAOIs and Diet: Is It Necessary to Restrict Tyramine? Journal of Research in Ayurveda and Siddha 1980;1(2):247-258. Ultimately, the supplements and foods you can . Kumar S, Bouic PJ, Rosenkranz B. Moderate 623 Interactions; Unknown 2123 Interactions; Interaction Rating Key. View abstract. low blood sugar). A systematic review and meta-analysis of randomized controlled trials. This product can contain high amounts of iron. Doses higher than that may interact with lexapro, or produce more pronounced effects. View abstract. Effect of standardized root extract of ashwagandha (Withania somnifera) on well-being and sexual performance in adult males: a randomized controlled trial. Dhuley, J. N. Effect of ashwagandha on lipid peroxidation in stress-induced animals. Speak with a, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Mediterranean, Low-Fat Diets Are Best for Heart Problems, Least Amount of Exercise You Need to Stay Healthy, Nerve 'Pulse' Therapy May Help Ease Sciatica, New Book: Take Control of Your Heart Disease Risk, MINOCA: The Heart Attack You Didnt See Coming, Health News and Information, Delivered to Your Inbox, Attention deficit-hyperactivity disorder (ADHD), Chronic obstructive pulmonary disease (COPD), Antipsychotic-induced metabolic side effects, Think Your Child Has ADHD? Panda S, Kar A. Withania somnifera and Bauhinia purpurea in the regulation of circulating thyroid hormone concentrations in female mice. Dongre S, Langade D, Bhattacharyya S. Efficacy and safety of ashwagandha (withania somnifera) root extract in improving sexual function in women: a pilot study. The combination could decrease the effectiveness of these medications. doi:10.7759/cureus.6466, Lopresti AL, Smith SJ, Malvi H, Kodgule R. An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: a randomized, double-blind, placebo-controlled study. You can also connect with Dr. Brian Staiger on LinkedIn. Sleep Med. Ashwagandha may be toxic to the liver (hepatotoxic). However, the review noted various limitations of the studies, including study design and potential bias. . Complement Ther Med. Nevertheless, be sure to talk to your doctor before adding on ashwagandha to blood pressure medicine, such as: Ashwagandha might increase the effects and adverse effects of thyroid hormone drugs. Devi, P. U., Sharada, A. C., Solomon, F. E., and Kamath, M. S. In vivo growth inhibitory effect of Withania somnifera (Ashwagandha) on a transplantable mouse tumor, Sarcoma 180. Front Pharmacol 2022;13:901710. Diarrhea. Ashwagandha and other dietary supplements should never replace standard medicine or care. View abstract. These severity listings are for informational use only. Next Steps to Take, Understanding Your Childs Life With ADHD. These side effects may be mild or severe. Khattak, S., Saeed, Ur Rehman, Shah, H. U., Khan, T., and Ahmad, M. In vitro enzyme inhibition activities of crude ethanolic extracts derived from medicinal plants of Pakistan. Safety and adverse events were also not well-reported in the studies used in the review. No supplement is intended to treat, cure, or prevent disease. People with thyroid conditions or who are taking thyroid medications should talk with a healthcare provider before using ashwagandha. St. John's wort can cause a buildup of serotonin in the body when taken with antidepressants. Some vitamins and supplements can interfere with blood-thinning blood pressure drugs, Dr. Glatter says. As this is a relatively new area of research, more vigorous studies are needed. However, certain vitamins, supplements and medications are processed via the same enzymatic pathway (cytochrome P450) as your antidepressants. Agnihotri AP, Sontakke SD, Thawani VR, Saoji A, Goswami VS. Take extra care if you are taking iron supplements. In general, Ashwagandha is thought to be safe when used in moderate amounts. Evid Based Complement Alternat Med. J Funct Morphol Kinesiol. Some medications, such as those used after a transplant, decrease the activity of the immune system. If you consume something that isn't recommended, you could end up reducing the effectiveness of your medication or increasing the likelihood of side effects. Effect of Indian Ayurvedic medicine Ashwagandha on measurement of serum digoxin and 11 commonly monitored drugs using immunoassays: study of protein binding and interaction with Digibind. While supplement and drug-induced serotonin syndrome poses a major risk for people taking SSRIs, other antidepressants can require stricter dietary changes. Its botanical name is Withania somnifera and it is also known as "Indian ginseng . Phytomedicine 2000;7(6):463-469. The most common side effects include: Other less common side effects of ashwagandha include: If you experience side effects when taking ashwagandha, be sure to stop using it and seek advice from a healthcare provider. Ashwagandha might increase how much thyroid hormone the body produces. View abstract. Ashwagandha has no known moderate interactions with any drugs. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. Chronic stress increases cortisol levels, leading to lower levels of T3 and T4. Choudhary, M. I., Nawaz, S. A., ul-Haq, Z., Lodhi, M. A., Ghayur, M. N., Jalil, S., Riaz, N., Yousuf, S., Malik, A., Gilani, A. H., and ur-Rahman, A. Withanolides, a new class of natural cholinesterase inhibitors with calcium antagonistic properties. Efficacy of Withania somnifera supplementation on adult's cognition and mood. Herb-drug interactions. Tumori 8-31-1994;80(4):306-308. Of the 58 participants in the study, those who took ashwagandha had reduced levels of cortisol (a stress hormone) as well as lower perceived stress scores by the end of the eight-week study. Indian J Pharmacol. The use of this information is governed by the Terms of Use, available at https://www.wolterskluwer.com/en/know/clinical-effectiveness-terms. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat. Ahumada F, Aspee F, Wikman G, and et al. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. It is commonly used for stress. Some people should avoid using ashwagandha due to safety concerns. Most reported drug interactions are based on the potential additive effectswhen combined with certain drugs (e.g. 2011;68(1):3-8. In 2020 and 2021, some people began using ashwagandha to diminish the harmful effects of COVID-19, although there is no evidence to support that use. 2016;5(4):40. doi:10.3390/antiox5040040, Vitale KC, Hueglin S, Broad E. Tart cherry juice in athletes: a literature review and commentary. However, some adverse effects are generally associated with ashwagandha. Cureus. Varying levels of research have looked at the potential benefits of ashwagandha. The herb has been proven to interact with many other drugs, the interaction with SSRI (selective serotonin reuptake inhibitor) or Benzodiazepines are not proven scientifically. J Diet Suppl. Because ashwagandha supports immune system function, it might interact with medications designed to reduce immune system activity, known as immunosuppressants, according to the University of Maryland Medical Center. 2021;16(9):e0257843. Ashwagandha may interact with various medications. 2021;6(1):20. doi:10.3390/jfmk6010020, Langade D, Kanchi S, Salve J, Debnath K, Ambegaokar D. Efficacy and safety of ashwagandha (Withania somnifera) root extract in insomnia and anxiety: a double-blind, randomized, placebo-controlled study. 2021;45(1):176. doi:10.1186/s42269-021-00635-6, White PT, Subramanian C, Motiwala HF, Cohen MS. Natural withanolides in the treatment of chronic diseases. J Clin Psychiatry. Ashwagandha can also interact with some medications and affect how they work. of signs you need emergency medical attention or call 911. Davis L, Kuttan G. Effect of Withania somnifera on cyclophosphamide-induced urotoxicity. A randomized double blind placebo controlled study of ashwagandha on generalized anxiety disorder. View abstract. Mixing tyramine and MAOI antidepressants can result in headache, nausea, anxiety, dangerously high blood pressure and even hemorrhagic stroke. doi:10.1371/journal.pone.0257843, Verma N, Gupta SK, Tiwari S, Mishra AK. Ashwagandha might cause sleepiness and slowed breathing. Be sure to tell your doctor if you are breastfeeding. 1981;19(3):245-249. Association of l-DOPA with recovery following Ayurveda medication in Parkinson's Disease. Ashwagandha interacts with several types of prescription medicine, so consult your health care provider before taking this herbal remedy. View abstract. Mishra LC, Singh BB, Dagenais S. Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review. Among the five cases, ashwagandha dosing ranged from 450 to 1,350 milligrams daily. Ashwagandha supplements are meant to be taken every day. I have it on my medical HelloPharmacist Be sure to tell your doctor that you take this product if you are scheduled for surgery or tests. Ashwagandha has no known moderate interactions with any drugs. Historically, ashwagandha has been thought of as a possible stimulant for athletics since the ancient medical system. Safety of ashwagandha root extract: a randomized, placebo-controlled, study in healthy volunteers. As with many other herbal supplements, little research is available on possible interactions. Due to an overall lack of scientific evidence, there are no standard dosage guidelines for ashwagandha. Chauhan S, Srivastava MK, Pathak AK. View abstract. Antioxidants (Basel). Another traditional use of ashwagandha in Ayurveda is for memory issues. These include drugs like thyroid desiccated, levothyroxine, or liotrix. 2020;40(4):825-829. doi:10.1111/liv.14393, Siddiqui S, Ahmed N, Goswami M, Chakrabarty A, Chowdhury G. DNA damage by withanone as a potential cause of liver toxicity observed for herbal products ofWithania somnifera(ashwagandha). Indian J Exp Biol. It is not meant to be comprehensive and should be used as a tool to help the user understand and/or assess potential diagnostic and treatment options. Examples of immunosuppressants include azathioprine, cyclosporine, mycophenolate, prednisone and corticosteroids. It is recommended that people with hormone-sensitive prostate cancer avoid using ashwagandha out of an abundance of caution. View abstract. This product may interfere with some lab tests. Liver Int. View abstract. Mandlik Ingawale DS, Namdeo AG. According to an August 2016 study in the Complementary Therapies in Medicine Journal, taking ashwagandha with antidepressants like SSRIs can be a safe, effective and healthy way of supporting your mental health. Phytother Res 2022. Ven Murthy, M. R., Ranjekar, P. K., Ramassamy, C., and Deshpande, M. Scientific basis for the use of Indian ayurvedic medicinal plants in the treatment of neurodegenerative disorders: ashwagandha. Hence, be cautious if taking these medications and want to take Ashwagandha also. Phytotherapy Research 1989;3(5):201-206. 1993;31(7):607-611. Begum, V. H. and Sadique, J. According to a December 2012 study in the Journal of Medicine and Life, SSRIs are primarily the recommended treatment for depression. Who Shouldn't Take Ashwagandha? Ashwagandha-induced liver injury: a case series from Iceland and the US Drug-Induced Liver Injury Network. Int.J.Crude Drug Res. Sriranjini SJ, Pal PK, Devidas KV, Ganpathy S. Improvement of balance in progressive degenerative cerebellar ataxias after Ayurvedic therapy: a preliminary report. Ashwagandha is purported as useful for relieving stress, fatigue, pain and gastrointestinal problems, and treating diabetes, rheumatoid arthritis and epilepsy. This information does not endorse any treatments or medications as safe, effective, or approved for treating a . Ashwaganda is used to treat Herbal Supplementation. 8-16-1995;95(1-2):189-193. Efficacy of Withania somnifera supplementation on adult's cognition and mood. Fertil Steril 2010;94:989-96. These side effects are usually experienced on higher doses. Although, it's important to note that long-term studies have not been performed on ashwagandha. Gastrointestinal side effects including nausea, vomiting and diarrhoea. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. View abstract. Biomed Res Int 2015;2015:284154.View abstract. View abstract. Cureus. Does Ashwagandha supplementation have a beneficial effect on the management of anxiety and stress? Agarwal R, Diwanay S, Patki P, Patwardhan B. Ashwagandha is popular in Ayurveda medicine, and Indians have used it for more than 3,000 years to treat a wide range of healthy disorders. UpToDate, Inc. and its affiliates disclaim any warranty or liability relating to this information or the use thereof. Afewerky HK, Ayodeji AE, Tiamiyu BB, et al. 2012;7(9):e44419. Phytother Res 1991;5:111-14. Ashwagandha has mild interactions with at least 29 different drugs. It is commonly used for stress. By Brittany Lubeck, RD An alternative treatment for anxiety: a systematic review of human trial results reported for the Ayurvedic herb ashwagandha (Withania somnifera). Staff. View abstract. Cookies collect information about your preferences and your devices and are used to make the site work as you expect it to, to understand how you interact with the site, and to show advertisements that are targeted to your interests. Ashwagandha is an evergreen shrub that grows in Asia and Africa. A total of 203 drugs are known to interact with levothyroxine .